Early Shift Work Disorder Study (NEJM Evidence)

Solriamfetol significantly improved sleepiness compared with placebo in early-morning shift workers with Shift Work Disorder.

We evaluated the efficacy of solriamfetol for treating excessive sleepiness in early-morning shift workers with shift work disorder. In this randomized, placebo-controlled trial of 78 participants, solriamfetol significantly improved wakefulness on the maintenance of wakefulness test (9.4-minute increase in sleep latency, 95% confidence interval [CI], 5.7 to 13.0; P<0.001) and reduced subjective sleepiness with consistent improvements across clinician- and patient-reported measures.

Zitting KM, Gilmore KR, Lockyer BJ, Leary EB, Wang W, Issa NC, Quan SF, Williams JS, Duffy JF, Czeisler CA. Solriamfetol for Excessive Sleepiness in Early-Morning Shift Work Disorder. NEJM Evid. 2026 Feb;5(2):EVIDoa2500190. doi: 10.1056/EVIDoa2500190. Epub 2026 Jan 27. PMID: 41590992.