Cheung J, Leary EB, Lu H, Zeitzer JM, Mignot E. PSG Validation of minute-to-minute scoring for sleep and wake periods in a consumer wearable device. PLOS One. 2020 Sep 17;15(9):e0238464. DOI: 10.1371/journal.pone.0238464. PMID: 32941498; PMCID: PMC7498244.
We investigated whether REM sleep is associated with greater risk of mortality in 2 independent cohorts and explored whether another sleep stage could be driving the findings.
This cross-sectional study from 2 independent cohorts found lower amounts of REM sleep were associated with increased risk of all-cause mortality. There was a 13% higher mortality rate over 12.1 years for every 5% reduction in REM sleep in a cohort of 2675 older men, and the finding was replicated in a cohort of 1375 middle-aged men and women followed-up for 20.8 years.
Article: https://jamanetwork.com/journals/jamaneurology/article-abstract/2767713
Leary EB, Watson KT, Ancoli-Israel S, Redline S, Yaffe K, Ravelo LA, Peppard PE, Zou J, Goodman S, Mignot E, Stone KL for the Osteoporotic Fractures in Men (MrOS) Study Research Group. Reduced REM Sleep is Associated with Mortality in Middle Aged and Older Adults. JAMA Neurol. Published online July 6, 2020. DOI:10.1001/jamaneurol.2020.2108. PMID: 32628261.
Leary EB*, Zinchuk A*, Sone KL, Mehra R. Update in Sleep 2019. Am J Respir Crit Care Med. 2020 Jun 15;201(12):1473-1479. DOI: 10.1164/rccm.202003-0586UP. PMID: 32293912 (* equal contribution)
Ambati A, Ju YE, Lin L, Olesen AN, Koch H, Hedou JJ, Leary, EB, Sempere V, Mignot, E; Taheri S. Proteomic biomarkers of sleep apnea. SLEEP 2020 May 5;zsaa086. DOI: 10.1093/sleep/zsaa086. PMID: 32369590.
Carvellia L, Olesen AN, Brink-Kjær A, Leary EB, Peppard PE, Mignot E, Sørensen HBD, Jennum PJ. Design of a deep learning model for automatic scoring of periodic and non-periodic leg movements during sleep validated against multiple human experts. Sleep Medicine, 2020 May: 109-119. DOI: 10.1016/j.sleep.2019.12.032.
Kim SJ, Kim S, Jeon S, Leary EB, Barwick F, Mignot E. Factors associated with fatigue in patients with insomnia. J Psychiatr Res. 2019 Oct;117:24-30. DOI: 10.1016/j.jpsychires.2019.06.021. Epub 2019 Jun 28. PMID: 31272015
Hanif U, Schneider LD, Trap L, Leary EB, Moore H, Guilleminault C, Jennum P, Sorensen HBD, Mignot EJM. Non-invasive machine learning estimation of effort differentiates sleep-disordered breathing pathology. Physiol Meas. 2019 Feb 26;40(2):025008. PMID 30736016.
Stephansen JB, Olesen AN, Olsen M, Ambati A, Leary EB, Moore HE, Carrillo O, Lin L, Han F, Yan H, Sun YL, Dauvilliers Y, Scholz S, Barateau L, Hogl B, Stefani A, Hong SC, Kim TW, Pizza F, Plazzi G, Vandi S, Antelmi, E, Perrin D, Kuna ST, Schweitzer PK, Kushida C, Peppard PE, Sørensen HB, Jennum P., Mignot E. Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy. Nat Commun., 2018 Dec 6;9(1):5229. PMID 30523329.
Leary EB, Moore H 4th, Schneider LD, Finn, LA, Peppard PE, Mignot E. Periodic Limb Movements During Sleep (PLMS): Prevalence and Associated Sleepiness in the Wisconsin Sleep Cohort. J Clin Neurophysiol. 2018 Nov;129(11):2306-2314. PMID 30243181.
Weaver MD, Vetter C, Rajaratnam SMW, O’Brien CS, Qadri S, Benca RM, Rogers AE, Leary EB, Walsh JK, Czeisler CA, Barger LK. Symptoms of sleep disorders, depression, and anxiety are associated with adverse safety outcomes in healthcare workers. J Sleep Res. 2018; 27 (6): e12722. PMID 30069960.
Koch H, Schneider LD, Finn LA, Leary EB, Peppard PE, Hagen E, Sorensen HBD, Jennum P, Mignot E. Breathing Disturbances Without Hypoxia Are Associated With Objective Sleepiness in Sleep Apnea. Sleep, 2017 Nov 1;40(11). PMID 29029253.
Olsen AV, Stephansen J, Leary E, Peppard P, Sheungshul H, Jennum P, Sørensen H, Mignot E. Diagnostic value of sleep stage dissociation as visualized on a 2-Dimensional sleep state space in human narcolepsy. J Neurosci Methods. 2017 Apr 15;282:9-19. PMID: 28219726.
Christensen JA, Carrillo O, Moore H 4th, Leary EB, Peppard P, Young T, Sorensen H, Jennum P, Mignot, E. Sleep stage transitions during polysomnographic recordings as diagnostic features of type 1 narcolepsy. Sleep Med. 2015 Jul 7. PMID:26299470.
Moore H 4th, Leary E, Lee SY, Carrillo O, Stubbs R, Peppard P, Young T, Widrow B, Mignot E. Design and validation of a periodic leg movement detector. PLoS One 2014 Dec 9;9(12):e114565. DOI: 10.1371/journal.pone.0114565. eCollection 2014. PMID:25489744.
Kushida CA, Nichols DA, Holmes TH, Quan SF, Walsh JK, Gottlieb DJ, Simon RD Jr, Guilleminault C, White DP, Goodwin JL, Schweitzer PK, Leary EB, Hyde PR, Hirshkowitz M, Green S, McEvoy LK, Chan C, Gevins A, Kay GG, Bloch DA, Crabtree T, Dement WC. Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: The Apnea Positive Pressure Long-term Efficacy Study (APPLES), Sleep. 2012 Dec 1;35(12):1593-602. PMID:21358847.