Suh S, Lok R, Weed L, Cho A, Mignot E, Leary EB; STAGES cohort investigator group; Zeitzer JM. Fatigued but not sleepy? An empirical investigation of the differentiation between fatigue and sleepiness in sleep disorder patients in a cross-sectional study. J Psychosom Res. 2024 Feb 9;178:111606. DOI: 10.1016/j.jpsychores.2024.111606. PMID: 38359639.
Husain AM, Zee PC, Leary EB, Fuller DS, Macfadden W, Candler S, Whalen M, Bae CJ. Dosing and transition characteristics in people with narcolepsy transitioning from sodium oxybate to low-sodium oxybate: Data from the real-world TENOR study. Sleep Med. 2024 Jan;113:328-337. DOI: 10.1016/j.sleep.2023.11.022. Epub 2023 Nov 25. PMID: 38103464.
Cederberg KLJ, Peris Sempere V, Lin L, Zhang J, Leary EB, Moore H, Morse AM, Blackman A, Schweitzer PK, Kotagal S, Bogan R, Kushida CA, STAGES Cohort Investigator Group, Mignot E. Proteomic insights into the pathophysiology of periodic limb movements and restless legs syndrome. Sleep Health. 2023 Aug 8:S2352-7218(23)00130-4. DOI: 10.1016/j.sleh.2023.06.008. PMID: 37563071.
Bae CJ, Zee PC, Leary EB, Fuller DS, Macfadden W, Candler S, Steininger TL, Husain AM. Effectiveness and tolerability in people with narcolepsy transitioning from sodium oxybate to low-sodium oxybate: Data from the real-world TENOR study. Sleep Med. 2023 Sep;109:65-74. DOI: 10.1016/j.sleep.2023.05.023. Epub 2023 Jun 19. PMID: 37421868.
Grandner MA, Min JS, Saad R, Leary EB, Eldemir L, Hyman D. Health-related impact of illness associated with excessive daytime sleepiness in patients with obstructive sleep apnea. Postgrad Med. 2023 May 2:1-10. DOI: 10.1080/00325481.2023.2203623. Epub ahead of print. PMID: 37129416.
Li K, Iwasaki T, Quo S, Leary EB, Li C, Guilleminault C. Nasomaxillary Expansion by Endoscopically-Assisted Surgical Expansion (EASE): An airway centric approach. Orthod Fr. 2022 Dec 1;93(Suppl 1):75-89. English. DOI: 10.1684/orthodfr.2022.97. PMID: 36704952.
Brink-Kjaer A, Leary EB, Sun H, Westover MB, Stone KL, Peppard PE, Lane NE, Cawthon PM, Redline S, Jennum P, Sorensen HBD, Mignot E. Age estimation from sleep studies using deep learning predicts life expectancy. NPJ Digit Med. 2022 Jul 22;5(1):103. DOI: 10.1038/s41746-022-00630-9. PMID: 35869169; PMCID: PMC9307657.
Cederberg KLJ, Hanif U, Peris Sempere V, Hédou J, Leary EB, Schneider LD, Lin L, Zhang J, Morse AM, Blackman A, Schweitzer PK, Kotagal S, Bogan R, Kushida CA, Ju YS, Petousi N, Turnbull CD, Mignot E, The Stages Cohort Investigator Group. Proteomic Biomarkers of the Apnea Hypopnea Index and Obstructive Sleep Apnea: Insights into the Pathophysiology of Presence, Severity, and Treatment Response. Int J Mol Sci. 2022 Jul 20;23(14):7983. DOI: 10.3390/ijms23147983. PMID: 35887329; PMCID: PMC9317550.
Hanif UR, Leary EB, Schneider LD, Paulsen RR, Morse AM, Blackman A, Schweitzer PK, Kushida CA, Liu SY, Jennum P, Sorensen HBD, Mignot E., Estimation of Apnea-Hypopnea Index using Deep Learning on 3D Craniofacial Scans. IEEE J Biomed Health Inform, 2021 May 7;PP. DOI: 10.1109/JBHI.2021.3078127. PMID: 33961569.
Read our thoughtful response to the editorial “Should Neurologists Be Concerned With REM Sleep Quantity?” written about our 2020 REM/Mortality study in JAMA Neurology.
Article: https://jamanetwork.com/journals/jamaneurology/article-abstract/2776791
Leary EB, Stone KL, Mignot E., Living to Dream - Reply JAMA Neurol. April 1, 2021. JAMA Neurol. 2021;78(4):495-496. DOI: 10.1001/jamaneurol.2021.0056. PMID: 33646274.
Cheung J, Leary EB, Lu H, Zeitzer JM, Mignot E. PSG Validation of minute-to-minute scoring for sleep and wake periods in a consumer wearable device. PLOS One. 2020 Sep 17;15(9):e0238464. DOI: 10.1371/journal.pone.0238464. PMID: 32941498; PMCID: PMC7498244.
We investigated whether REM sleep is associated with greater risk of mortality in 2 independent cohorts and explored whether another sleep stage could be driving the findings.
This cross-sectional study from 2 independent cohorts found lower amounts of REM sleep were associated with increased risk of all-cause mortality. There was a 13% higher mortality rate over 12.1 years for every 5% reduction in REM sleep in a cohort of 2675 older men, and the finding was replicated in a cohort of 1375 middle-aged men and women followed-up for 20.8 years.
Article: https://jamanetwork.com/journals/jamaneurology/article-abstract/2767713
Leary EB, Watson KT, Ancoli-Israel S, Redline S, Yaffe K, Ravelo LA, Peppard PE, Zou J, Goodman S, Mignot E, Stone KL for the Osteoporotic Fractures in Men (MrOS) Study Research Group. Reduced REM Sleep is Associated with Mortality in Middle Aged and Older Adults. JAMA Neurol. Published online July 6, 2020. DOI:10.1001/jamaneurol.2020.2108. PMID: 32628261.
Leary EB*, Zinchuk A*, Sone KL, Mehra R. Update in Sleep 2019. Am J Respir Crit Care Med. 2020 Jun 15;201(12):1473-1479. DOI: 10.1164/rccm.202003-0586UP. PMID: 32293912 (* equal contribution)
Ambati A, Ju YE, Lin L, Olesen AN, Koch H, Hedou JJ, Leary, EB, Sempere V, Mignot, E; Taheri S. Proteomic biomarkers of sleep apnea. SLEEP 2020 May 5. DOI: 10.1093/sleep/zsaa086. PMID: 32369590.
Carvellia L, Olesen AN, Brink-Kaera A, Leary EB, Peppard PE, Mignot E, Sørensen HBD, Jennum PJ. Design of a deep learning model for automatic scoring of periodic and non-periodic leg movements during sleep validated against multiple human experts. Sleep Medicine, 2020 May: 109-119. DOI: 10.1016/j.sleep.2019.12.032.